カドミウム誘導性水素蓄積はグルタチオン恒常性の再確立を通じてブラッシカ・カンペストリスのカドミウム耐性に関与する
This study examined the physiological role of hydrogen-rich water (HRW) in Brassica campestris seedlings exposed to cadmium (Cd) stress. Both 50 μM CdCl2 and HRW at 50% saturation elevated endogenous H2 levels. HRW application reduced growth inhibition and oxidative damage caused by Cd. Seedlings receiving HRW showed greater root elongation, lower lipid peroxidation, elevated reduced glutathione (GSH) and ascorbic acid (AsA) concentrations, and higher GST and GPX enzymatic activities in roots. At the molecular level, expression of GS, GR1, and GR2 genes—suppressed by Cd, GSH, or BSO—was partially restored by HRW supplementation. These findings indicate that H2 functions as a regulator of GSH homeostasis, thereby enhancing Cd tolerance in Brassica campestris seedlings.
H2 restores expression of GSH biosynthesis and recycling genes (GS, GR1, GR2), thereby re-establishing reduced glutathione and ascorbic acid homeostasis and mitigating cadmium-induced oxidative stress in plant roots.
Hydrogen-rich water is a low-risk delivery route, but the achievable systemic hydrogen dose is bounded. For clinical applications, inhalation is the most efficient route; inhalation, however, carries explosion risk, and concentration matters (empirical LFL of 10% applies to inhalation environments; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).
See also:
https://h2-papers.org/en/papers/26445361