マクロポーラス水系ポリウレタン-キトサンハイドロゲル足場による全層皮膚創傷の治癒促進
Full-thickness dermal wounds require exogenous scaffold support to restore tissue integrity. In this study, waterborne polyurethane diol dispersion was blended with antibacterial chitosan at varying ratios, yielding macroporous hydrogel scaffolds (MHS) through room-temperature self-organization upon drying. Structural characterization via SEM and AFM confirmed macroporosity on both surface and fracture planes, while FTIR analysis identified intermolecular hydrogen bonding as the driver of phase separation between the two polymers. Mechanical performance, in vitro degradation under hydrolytic, enzymatic, and pH-variable conditions, and primary rat fibroblast cytocompatibility were all found acceptable. In a Wistar rat full-thickness wound model, MHS-treated wounds exhibited superior wound contraction, elevated collagen deposition, and enhanced vascularization relative to a commercial polyurethane-based dressing. These findings indicate that the developed MHS holds considerable promise as a wound dressing material for full-thickness skin defects.
Intermolecular hydrogen bonding between polyurethane and chitosan drives phase separation, forming a macroporous architecture that promotes fibroblast proliferation, collagen synthesis, and vascularization to accelerate wound closure.
Topical applications have localized-effect reports, but systemic hydrogen intake is most efficient via inhalation. Inhalation carries explosion risk (empirical LFL of 10%; high-concentration devices are not recommended).
See also:
https://h2-papers.org/en/papers/28887957