褥瘡に対する可視光触媒による局所水素・温熱併用産生の新戦略
Pressure ulcers (PU) are notoriously difficult to resolve because repeated mechanical loading drives ischemia-reperfusion injury, impairs microcirculation, and sustains chronic inflammation. This study developed palladium nanodot-decorated hydrogen-doped titanium dioxide nanorods (HTON-Pd) as a multifunctional photocatalyst capable of generating molecular hydrogen and localized warmth simultaneously under visible-light irradiation. When incorporated into a hydrogel dressing (HTON-Pd@Gel) and applied daily with visible-light exposure, complete wound closure of refractory PU was achieved within 11 days in an animal model. Mechanistic investigation revealed that the photocatalytically produced hydrogen and heat acted synergistically to enhance skin-cell proliferation and migration, suppress apoptosis, attenuate inflammatory signaling, and stimulate neovascularization, collectively improving the wound microenvironment.
HTON-Pd photocatalytically generates H2 and localized heat under visible light; together they promote skin-cell proliferation and migration, inhibit apoptosis, reduce inflammatory responses, and stimulate angiogenesis, thereby accelerating wound repair.
Topical applications have localized-effect reports, but systemic hydrogen intake is most efficient via inhalation. Inhalation carries explosion risk (empirical LFL of 10%; high-concentration devices are not recommended).
See also:
https://h2-papers.org/en/papers/40491331