酸応答性水素放出型2D MgBナノシートによる胃がん化学療法の相乗効果と副作用軽減
Molecular hydrogen has attracted attention for its potential to both reduce chemotherapy-associated toxicity and augment antitumor efficacy. In this study, two-dimensional magnesium boride nanosheets (MBN) were fabricated via an ultrasound-assisted chemical etching method and evaluated as an acid-responsive hydrogen-releasing prodrug system. Polyvinylpyrrolidone-encapsulated MBN (MBN@PVP) pills demonstrated high stability under physiological conditions while exhibiting sustained hydrogen release in acidic gastric environments, aligning with gastric metabolism kinetics. Combined oral administration of MBN@PVP with intravenous doxorubicin (DOX) in gastric tumor-bearing mice significantly extended survival compared to chemotherapy alone. Mechanistic investigation revealed that hydrogen molecules selectively suppressed aerobic respiration in gastric cancer cells while activating it in normal cells, including bone marrow mesenchymal stem cells and cardiac, hepatic, and splenic cells, thereby explaining both the synergistic antitumor effect and the attenuation of systemic side effects.
Hydrogen molecules selectively inhibit aerobic respiration in gastric cancer cells while activating it in normal cells (bone marrow mesenchymal stem cells, cardiac, hepatic, and splenic cells), producing simultaneous antitumor synergy and reduction of chemotherapy-related toxicity.
This study combines multiple delivery routes. As a general principle, the most efficient route for routine hydrogen intake is inhalation. Inhalation carries explosion risk (empirical LFL of 10%; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).
See also:
https://h2-papers.org/en/papers/30968583