マイクロ・ナノ材料を活用した水素医療の増強戦略に関するレビュー
Molecular hydrogen exhibits bio-reductive and homeostatic properties that confer beneficial effects against oxidative stress- and inflammation-related conditions. Unlike gaseous transmitters such as NO, CO, and H2S, H2 does not interfere with oxygen transport by erythrocytes, making high-concentration exposure relatively safe. However, its low aqueous solubility and non-directional diffusion limit site-specific efficacy. This review introduces the concept of hydrogen nanomedicine, systematically organizing approaches that employ functional micro/nanomaterials to achieve targeted hydrogen delivery, controlled release, and nanocatalytic or multimodal enhancement of hydrogen efficacy. These strategies are presented as a framework for advancing the investigation of hydrogen's effects on inflammation-related diseases.
H2 exerts bio-reductive effects and modulates homeostatic pathways to suppress oxidative stress and inflammation. Functional micro/nanomaterials enable targeted delivery and controlled release, increasing local H2 concentration and enhancing efficacy at disease sites.
This study combines multiple delivery routes. As a general principle, the most efficient route for routine hydrogen intake is inhalation. Inhalation carries explosion risk (empirical LFL of 10%; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).
See also:
https://h2-papers.org/en/papers/31267691