分子状水素の放射線防護剤としての可能性：メカニズムと投与方法のレビュー
Ionizing radiation causes biological damage primarily through hydroxyl radicals generated by the radiolysis of water. Molecular hydrogen, owing to its selective scavenging of reactive oxygen species, may reduce such radiation-induced injury via multiple mechanistic pathways. This review examines the radioprotective mechanisms attributed to hydrogen, evaluates various delivery strategies, and surveys findings from cell-based and animal studies as well as available clinical data. The authors conclude that existing evidence supports continued investigation of hydrogen as a radioprotective agent, highlighting the need for expanded research in this area.
Molecular hydrogen selectively neutralizes hydroxyl radicals produced by water radiolysis under ionizing radiation, thereby reducing oxidative damage through multiple downstream pathways.
This study combines multiple delivery routes. As a general principle, the most efficient route for routine hydrogen intake is inhalation. Inhalation carries explosion risk (empirical LFL of 10%; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).
See also:
https://h2-papers.org/en/papers/32763820