腸管炎症時における腸内細菌の分子状水素代謝の再編成と腸内細菌科の増殖への寄与
During intestinal inflammation, gut microbial community composition shifts, with notable expansion of Enterobacteriaceae. This study examined published metagenomic datasets from both murine colitis models and inflammatory bowel disease patients, focusing on hydrogen metabolism genes. Bacterial genomes recovered from inflamed gut environments harbored a greater abundance of genes encoding hydrogen-utilizing hydrogenases compared to non-inflamed conditions. Functional validation using a representative Enterobacteriaceae species demonstrated that strains lacking hydrogenase-1 and hydrogenase-2 showed reduced colonization fitness in the inflamed cecum and colon. The utilization of molecular hydrogen was found to depend partly on respiration using inflammation-derived electron acceptors. These findings indicate that hydrogenase activity contributes to microbiota compositional shifts observed in non-infectious colitis.
Hydrogenase-1 and hydrogenase-2 enable Enterobacteriaceae to oxidize molecular hydrogen, coupling this process to respiration using inflammation-derived electron acceptors, thereby enhancing colonization fitness in the inflamed gut.
This is basic research at the cellular or molecular level. For human application, inhalation is the most promising delivery route, but inhalation carries explosion risk and concentration matters (empirical LFL of 10%; high-concentration devices are not recommended).
See also:
https://h2-papers.org/en/papers/34085924