糖尿病性創傷治癒を促進する水素産生藻類-細菌共生ドレッシング材の開発
Oxidative stress arising from hyperglycemia and chronic inflammation impairs diabetic wound repair, often progressing to foot ulcers. Conventional hydrogen delivery formats—gas, hydrogen-rich water, and saline—suffer from rapid dissipation due to low gas solubility. To address this limitation, a living microbe-based hydrogel was constructed by encapsulating algae and bacteria within a cell-impermeable matrix, enabling continuous hydrogen generation for up to 60 hours. The system demonstrated selective scavenging of highly reactive hydroxyl radicals (•OH) and peroxynitrite (ONOO⁻), along with suppression of inflammatory responses. In diabetic wound models, the dressing promoted cell proliferation and improved wound closure by approximately 50% by day 3 compared to controls. The algae-bacteria symbiotic hydrogel exhibited favorable biocompatibility and sustained reactive oxygen species neutralization capacity, supporting its potential for clinical wound management.
The symbiotic algae-bacteria hydrogel continuously generates hydrogen for 60 hours, selectively neutralizing hydroxyl radicals and peroxynitrite, thereby reducing oxidative stress and inflammation to promote diabetic wound healing.
Topical applications have localized-effect reports, but systemic hydrogen intake is most efficient via inhalation. Inhalation carries explosion risk (empirical LFL of 10%; high-concentration devices are not recommended).
See also:
https://h2-papers.org/en/papers/34928162