メタンフェタミン誘発うつ様行動における高体温の役割：コーラルカルシウムハイドライドの保護効果
Methamphetamine (METH) abuse inflicts irreversible harm on the central nervous system, producing psychiatric manifestations such as depression. This study examined the contribution of hyperthermia to METH-associated depression-like behaviors in mice exposed to either normal or elevated ambient temperatures. High ambient temperature was found to exacerbate METH-induced hyperthermia and was essential for the emergence of depression-like behaviors; chronic METH exposure under normal temperature alone did not produce these behaviors. High ambient temperature also worsened hippocampal synaptic plasticity impairment, oxidative stress responses, and neuroinflammation. Coral calcium hydride (CCH), a hydrogen-rich powder that releases hydrogen gas upon contact with water, was evaluated as an intervention. CCH pretreatment markedly reduced METH-induced hyperthermia, while post-exposure CCH administration suppressed depression-like behaviors and attenuated hippocampal synaptic plasticity damage. CCH also lowered lactate dehydrogenase activity and reduced hippocampal levels of malondialdehyde, TNF-α, and IL-6, indicating antioxidant and anti-inflammatory actions.
CCH releases molecular hydrogen upon contact with water; the hydrogen scavenges reactive oxygen species, thereby reducing oxidative stress markers (MDA, LDH) and suppressing neuroinflammatory mediators (TNF-α, IL-6) to preserve hippocampal synaptic plasticity.
This study is at the animal-experiment stage. For human application, inhalation is the most promising delivery route, but inhalation carries explosion risk and concentration matters (empirical LFL of 10%; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).
See also:
https://h2-papers.org/en/papers/35058751