水素富化水は大腸癌異種移植モデルにおいて5-フルオロウラシルと同等の抗腫瘍効果を示す
A colorectal cancer (CRC) xenograft model was established in the left flank of inbred Balb/c mice. Twenty-four tumor-bearing animals were allocated to four groups: control, 5-fluorouracil (5-FU; 5 mg/kg intraperitoneally every other day), hydrogen-rich water (HRW; delivered via drinking water with H2-generating tablets plus 200 µL oral gavage), and a combination of HRW with 5-FU. HRW administration was associated with reduced oxidative stress and enhanced antioxidant activity, whereas 5-FU alone increased oxidative stress and diminished antioxidant capacity. The combined regimen produced significant reductions in tumor weight, tumor volume, collagen deposition, and fibrosis relative to the untreated control, though oxidative stress remained elevated compared with HRW alone. Notably, HRW as a single intervention achieved anti-tumor outcomes comparable to those of 5-FU, suggesting a potential role for molecular hydrogen in CRC management.
HRW suppresses tumor growth by reducing oxidative stress and enhancing antioxidant activity. When combined with 5-FU, tumor weight and size reductions are amplified additively, although antioxidant capacity is diminished compared with HRW alone, indicating distinct mechanistic contributions from each agent.
Hydrogen-rich water is a low-risk delivery route, but the achievable systemic hydrogen dose is bounded. For clinical applications, inhalation is the most efficient route; inhalation, however, carries explosion risk, and concentration matters (empirical LFL of 10% applies to inhalation environments; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).
See also:
https://h2-papers.org/en/papers/35116114