ストレプトゾトシン誘発糖尿病ラットにおける水素水投与がインスリン・インスリン受容体・SODに与える影響
Thirty male Wistar rats were allocated to five groups—normal control, STZ-induced diabetic, diabetic plus metformin (45 mg/kg), diabetic plus metformin plus hydrogen-rich water (HW), and diabetic plus HW alone—to examine the metabolic effects of HW. Diabetes was established by a 30-day high-fat diet followed by repeated low-dose intraperitoneal STZ injections (35 mg/kg). HW was administered orally for 14 days. Compared with untreated diabetic animals, HW-treated rats showed elevated insulin concentrations, increased insulin receptor (IRs) expression, and higher superoxide dismutase (SOD) activity in both serum and liver tissue. No statistically significant differences were detected between the HW-only group and the metformin group, suggesting that HW exerts antioxidant activity comparable to the reference drug in this STZ model.
Hydrogen-rich water is proposed to scavenge reactive oxygen species, thereby enhancing superoxide dismutase activity and restoring insulin secretion and insulin receptor expression in STZ-damaged pancreatic and hepatic tissue.
Hydrogen-rich water is a low-risk delivery route, but the achievable systemic hydrogen dose is bounded. For clinical applications, inhalation is the most efficient route; inhalation, however, carries explosion risk, and concentration matters (empirical LFL of 10% applies to inhalation environments; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).
See also:
https://h2-papers.org/en/papers/35369585