過体重者における分子状水素の摂取が脳内グルタミン酸/GABA-グルタミンサイクルに与える影響
This pilot study examined the impact of 12-week molecular hydrogen (H2) intake on brain neurotransmitter metabolites in five overweight adults (three women; mean age 50.2 ± 11.9 years; BMI 29.4 ± 2.1 kg/m²). Using 1.5-T single-voxel proton magnetic resonance spectroscopy, researchers measured concentrations of key amino acid neurotransmitters involved in appetite regulation. Following H2 intake, statistically significant reductions were observed in glutamate and combined glutamate-plus-glutamine levels at the posterior cingulate gyrus, GABA levels at the left prefrontal white matter, and glutathione levels at the anterior cingulate gyrus. A historical comparison group of four overweight individuals who had not received H2 showed no equivalent metabolite changes. The authors propose that H2 may modulate neurotransmitter pathways linked to appetite stimulation, potentially contributing to hunger suppression and weight reduction. Future investigations are recommended to include additional satiation and satiety biomarkers across varied dietary conditions.
H2 intake was associated with reduced glutamate, glutamate-plus-glutamine, and GABA concentrations in appetite-regulating brain regions, suggesting modulation of the glutamate/GABA-glutamine neurotransmitter cycle that may suppress hunger signaling.
Hydrogen-rich water is a low-risk delivery route, but the achievable systemic hydrogen dose is bounded. For clinical applications, inhalation is the most efficient route; inhalation, however, carries explosion risk, and concentration matters (empirical LFL of 10% applies to inhalation environments; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).
See also:
https://h2-papers.org/en/papers/37560746