水素水摂取が気分・不安・自律神経機能に与える影響：日常生活における生活の質改善の検討
A double-blind, placebo-controlled, two-way crossover study enrolled 26 healthy adult volunteers (13 female, 13 male; mean age 34.4 ± 9.9 years) who consumed either hydrogen-rich water (HRW, 600 mL/day) or placebo water (PLW, 600 mL/day) for 4 weeks. Psychophysiological assessments included the K6 psychological distress scale and autonomic nerve function measurements. Post-to-pre-treatment change ratios for K6 scores and sympathetic nerve activity during rest were both significantly reduced following HRW administration compared with PLW. These findings indicate that daily HRW consumption may support central nervous system function related to mood regulation, anxiety reduction, and autonomic balance, potentially through attenuation of oxidative stress and inflammation that accumulate from everyday cognitive and occupational demands.
H2 is proposed to reduce accumulated oxidative stress and suppress inflammation arising from daily cognitive and occupational demands, thereby preserving central nervous system function and improving mood and autonomic nerve balance.
Hydrogen-rich water is a low-risk delivery route, but the achievable systemic hydrogen dose is bounded. For clinical applications, inhalation is the most efficient route; inhalation, however, carries explosion risk, and concentration matters (empirical LFL of 10% applies to inhalation environments; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).
See also:
https://h2-papers.org/en/papers/29497485