分子状水素の皮膚美容医学への応用に関する進展レビュー
This review examines the biological roles of molecular hydrogen (H2) in skin cosmetology. H2 is a small, colorless, biologically active gas with reducing properties that acts through selective antioxidation, anti-inflammatory mechanisms, apoptosis inhibition, and modulation of gene expression and signaling pathways. In skin tissue, H2 scavenges free radicals and suppresses oxidative stress, contributing to improvements in skin texture and tone. Regulation of inflammatory responses reduces redness and pruritus while supporting skin repair and regeneration. Activation of antioxidant enzymes in skin cells enhances their intrinsic antioxidant capacity, potentially delaying aging. Clinical evidence indicates beneficial effects on acne, chloasma, and skin sensitivity. Nevertheless, the field remains at an early stage, with unresolved questions surrounding optimal dosing, precise mechanisms, and long-term safety profiles. The authors propose that expanded, well-designed clinical trials are necessary to advance H2 applications in dermatological cosmetology.
H2 selectively neutralizes reactive oxygen species such as hydroxyl radicals, activates antioxidant enzymes via the Nrf2 pathway, suppresses pro-inflammatory signaling, and modulates apoptosis-related pathways, collectively protecting skin cells from oxidative and inflammatory damage.
This study combines multiple delivery routes. As a general principle, the most efficient route for routine hydrogen intake is inhalation. Inhalation carries explosion risk (empirical LFL of 10%; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).
See also:
https://h2-papers.org/en/papers/40061044