The Effects of 8-Week Hydrogen-Rich Water Consumption on Appetite, Body Composition, Sleep Quality, and Circulating Glucagon-like Peptide-1 in Obese Men and Women (HYDRAPPET): A Randomized Controlled Trial.
水素水8週間摂取が肥満男女の食欲・体組成・睡眠の質およびGLP-1に与える影響：無作為化対照試験（HYDRAPPET）
Abstract
This double-blind, placebo-controlled randomized trial enrolled 36 obese participants (24 female; mean age 42.1 ± 13.2 years; BMI 30.8 ± 4.2 kg/m²) who consumed either 1.0 L of hydrogen-rich water (15 mg H₂) or 1.0 L of plain control water daily over eight weeks. Compared with the control group, the hydrogen-rich water group showed significant reductions in food cravings (p = 0.05), improvements in subjective sleep quality (p = 0.05), decreases in total cholesterol (p = 0.02) and LDL cholesterol (p = 0.04), and elevated plasma glucagon-like peptide-1 (GLP-1) concentrations (p = 0.05). No serious adverse events were observed during the intervention period. These results indicate that hydrogen-rich water may beneficially influence appetite-related and metabolic parameters in individuals with obesity.
Mechanism
Hydrogen-rich water consumption was associated with elevated circulating GLP-1 levels, which may enhance satiety signaling, alongside improvements in lipid metabolism markers including total and LDL cholesterol.
Bibliographic
- Authors
- Todorovic N, Baltic S, Nedeljkovic D, Kuzmanovic J, Korovljev D, Javorac D, et al.
- Journal
- Medicina (Kaunas)
- Year
- 2025 (2025-07-18)
- PMID
- 40731927
- DOI
- 10.3390/medicina61071299
- PMC
- PMC12300559
Tags
Delivery context
Hydrogen-rich water is a low-risk delivery route, but the achievable systemic hydrogen dose is bounded. For clinical applications, inhalation is the most efficient route; inhalation, however, carries explosion risk, and concentration matters (empirical LFL of 10% applies to inhalation environments; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).
Safety notes
See also: