antioxidant enzymes

423 papers

Research evidence summary

Q: Does molecular hydrogen help with antioxidant enzymes?

A: Of 423 peer-reviewed papers, 305 reported a positive effect (the most common), 38 limited/mixed, 3 negative, 77 not assessed. Study mix: 80 human (45 RCT), 222 animal/basic, 75 meta-analysis or synthesis. The most studied delivery route is hydrogen-rich water. The above aggregates published research and does not constitute a clinically established conclusion. See the individual paper pages for details and Safety notes for inhalation safety. (last updated 2026-05-15)

Evidence breakdown
Human	80	of which RCT	45
Animal/basic	222	Synthesis/meta	75
Reported effect	positive 305 ・ limited/mixed 38 ・ negative 3 ・ not assessed 77

Read the safety notes →

Delivery-method distribution

hydrogen-rich water: 179 in vitro: 65 inhalation: 48 mixed routes: 47 injection / infusion: 36 not specified: 30 animal model: 8 topical application: 7 hydrogen bath: 3

Evaluation of the impact of hydrogen-rich water on the quality attribute notes of butter.
2022 ・ J Dairy Res ・ PMID 36408665

hydrogen-rich water positive other
Effects of hydrogen rich water and pure water on periodontal inflammatory factor level, oxidative stress level and oral flora: a systematic review and meta-analysis.
2022 ・ Ann Transl Med ・ PMID 36388830

hydrogen-rich water positive meta-analysis
Treatment with Hydrogen-Rich Water Improves the Nociceptive and Anxio-Depressive-like Behaviors Associated with Chronic Inflammatory Pain in Mice.
2022 ・ Antioxidants (Basel) ・ PMID 36358525

injection / infusion positive animal study
Hydrogen-Rich Water Mitigates LPS-Induced Chronic Intestinal Inflammatory Response in Rats via Nrf-2 and NF-κB Signaling Pathways.
2022 ・ Vet Sci ・ PMID 36356098

hydrogen-rich water positive animal study
Silicon nanoparticles for oral administration of molecular hydrogen.
2022 ・ Int J Pharm ・ PMID 36351504

in vitro positive in vitro study
Dynamics of Metabolic and Oxidative Parameters of Erythrocytes during Treatment of Chronic Heart Failure with Molecular Hydrogen.
2022 ・ Bull Exp Biol Med ・ PMID 36210415

inhalation positive human observational study
Molecular Hydrogen Reduces Electromagnetic Pulse-Induced Male Rat Reproductive System Damage in a Rodent Model.
2022 ・ Oxid Med Cell Longev ・ PMID 36199428

hydrogen-rich water positive animal study
Using a high-throughput, whole-cell hydrogenase assay to identify potential small molecule inhibitors of [NiFe]-hydrogenase.
2022 ・ Metallomics ・ PMID 36190308

in vitro mixed in vitro study
Hydrogen-Rich Water as a Novel Therapeutic Strategy for the Affective Disorders Linked with Chronic Neuropathic Pain in Mice.
2022 ・ Antioxidants (Basel) ・ PMID 36139900

hydrogen-rich water positive animal study
Structural changes and exposed amino acids of ethanol-modified whey proteins isolates promote its antioxidant potential.
2022 ・ Curr Res Food Sci ・ PMID 36110385

in vitro positive in vitro study
Prophylactic Instillation of Hydrogen-Rich Water Decreases Corneal Inflammation and Promotes Wound Healing by Activating Antioxidant Activity in a Rat Alkali Burn Model.
2022 ・ Int J Mol Sci ・ PMID 36077171

topical application positive animal study
Antioxidation activity of molecular hydrogen via protoheme catalysis in vivo: an insight from ab initio calculations.
2022 ・ J Mol Model ・ PMID 36057001

in vitro positive in vitro study
Malproduction of endogenous hydrogen gas in COVID-19.
2022 ・ Front Cell Infect Microbiol ・ PMID 35967841

not specified not assessed review
Impact of nutraceuticals and dietary supplements on mitochondria modifications in healthy aging: a systematic review of randomized controlled trials.
2022 ・ Aging Clin Exp Res ・ PMID 35920994

mixed routes positive meta-analysis
Transcriptome and Metabonomics Combined Analysis Revealed the Defense Mechanism Involved in Hydrogen-Rich Water-Regulated Cold Stress Response of.
2022 ・ Front Plant Sci ・ PMID 35812920

hydrogen-rich water positive other
Discovering and Evaluating the Reducing Abilities of Polar Alkanes and Related Family Members as Organic Reductants Using Thermodynamics.
2022 ・ J Org Chem ・ PMID 35786938

in vitro not assessed other
Effects of hydrogen water and psychological treatment in a sample of women with panic disorder: a randomized and controlled clinical trial.
2022 ・ Health Psychol Res ・ PMID 35774917

hydrogen-rich water mixed human randomized controlled trial
Hydrogen Gas Inhalation Regressed Coronary Artery Aneurysm in Kawasaki Disease-Case Report and Article Review.
2022 ・ Front Cardiovasc Med ・ PMID 35647081

inhalation positive human case report
Is It a Challenge to Use Molecular Hydrogen for Extending Flower Vase Life?
2022 ・ Plants (Basel) ・ PMID 35631701

not specified not assessed review
Short-Term Consumption of Hydrogen-Rich Water Enhances Power Performance and Heart Rate Recovery in Dragon Boat Athletes: Evidence from a Pilot Study.
2022 ・ Int J Environ Res Public Health ・ PMID 35564808

hydrogen-rich water mixed human randomized controlled trial
The improvement of insulin level after hydrogen-rich water therapy in streptozotocin-induced diabetic rats.
2022 ・ Vet World ・ PMID 35369585

hydrogen-rich water positive animal study
Integrated Metabolomic and Transcriptomic Analyses to Understand the Effects of Hydrogen Water on the Roots of.
2022 ・ Plants (Basel) ・ PMID 35270073

hydrogen-rich water positive in vitro study
Effects of hydrogen-rich water and ascorbic acid treatment on spontaneously hypertensive rats.
2022 ・ Exp Anim ・ PMID 35264492

hydrogen-rich water positive animal study
Molecular hydrogen is a potential protective agent in the management of acute lung injury.
2022 ・ Mol Med ・ PMID 35240982

mixed routes not assessed review
Molecular Hydrogen Positively Affects Physical and Respiratory Function in Acute Post-COVID-19 Patients: A New Perspective in Rehabilitation.
2022 ・ Int J Environ Res Public Health ・ PMID 35206179

inhalation positive human randomized controlled trial