水素水が慢性神経障害性疼痛に伴う情動障害に及ぼす影響：マウスを用いた検討
Using a chronic constriction injury (CCI) model of the sciatic nerve in male mice, this study examined how repeated administration of hydrogen-rich water (HRW) affects neuropathic pain and associated mood disturbances. HRW suppressed both allodynia and hyperalgesia induced by CCI, while also reducing anxiety-like and depressive-like behaviors. Mechanistic analyses indicated that antioxidant enzymes—heme oxygenase 1 (HO-1) and NAD(P)H:quinone oxidoreductase 1 (NQO1)—along with ATP-sensitive potassium channels, contribute to the analgesic effects of HRW. A positive interaction between the HO-1 enzyme system and molecular hydrogen was identified during neuropathic conditions. In dorsal root ganglia and amygdala tissue from nerve-injured animals, antioxidant, anti-inflammatory, and antiapoptotic effects were also documented.
HRW activates antioxidant enzymes HO-1 and NQO1 and ATP-sensitive potassium channels, reducing oxidative stress, inflammation, and apoptosis in dorsal root ganglia and amygdala, thereby alleviating neuropathic pain and mood-related deficits.
Hydrogen-rich water is a low-risk delivery route, but the achievable systemic hydrogen dose is bounded. For clinical applications, inhalation is the most efficient route; inhalation, however, carries explosion risk, and concentration matters (empirical LFL of 10% applies to inhalation environments; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).
See also:
https://h2-papers.org/en/papers/36139900