パニック障害女性における水素水と心理的介入の複合効果：無作為化対照臨床試験
This randomized placebo-controlled trial enrolled women diagnosed with panic disorder to compare a combination of psychological intervention plus 1.5 L/day of hydrogen-rich water for three months against psychological intervention plus placebo. On the primary endpoints of anxiety and depression severity, no statistically significant between-group advantage was detected for the hydrogen-rich water group. However, that group showed a greater reduction in pro-inflammatory cytokine levels along with improvements in body pain and physical health scores. When between-group differences were statistically removed, psychological intervention alone produced significant decreases across multiple measured variables, including cytokine concentrations and the cortisol awakening response. The findings indicate that a maladaptive inflammatory process is present in women with panic disorder, and that hydrogen-rich water may contribute to modulating inflammatory markers even when its effect on anxiety severity does not reach significance.
Hydrogen-rich water is proposed to exert antioxidant and anti-inflammatory effects that reduce pro-inflammatory cytokine levels, thereby partially suppressing the maladaptive inflammatory processes associated with panic disorder.
Hydrogen-rich water is a low-risk delivery route, but the achievable systemic hydrogen dose is bounded. For clinical applications, inhalation is the most efficient route; inhalation, however, carries explosion risk, and concentration matters (empirical LFL of 10% applies to inhalation environments; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).
See also:
https://h2-papers.org/en/papers/35774917