水素水投与による心筋虚血再灌流障害の軽減とJAK2-STAT3シグナル経路の関与
Using 20 male Wistar rats, this study investigated how hydrogen-rich water influences myocardial ischaemia-reperfusion injury. Protein chip analysis of left ventricular tissue revealed that 25 proteins spanning five transduction pathways were downregulated in the hydrogen-rich water group. Western blot and immunohistochemical assessments showed elevated p-JAK2/JAK2 and p-STAT3/STAT3 ratios alongside reduced p-STAT1/STAT1 expression in hydrogen-rich water-treated animals compared with controls. TUNEL staining demonstrated a significant reduction in cardiomyocyte apoptosis in the hydrogen-rich water group. These findings indicate that hydrogen-rich water may confer cardioprotection following ischaemia-reperfusion by activating the JAK2-STAT3 signalling axis while suppressing STAT1 phosphorylation.
Hydrogen-rich water upregulates JAK2 and STAT3 phosphorylation while downregulating STAT1 phosphorylation, thereby reducing cardiomyocyte apoptosis and attenuating myocardial ischaemia-reperfusion injury.
Hydrogen-rich water is a low-risk delivery route, but the achievable systemic hydrogen dose is bounded. For clinical applications, inhalation is the most efficient route; inhalation, however, carries explosion risk, and concentration matters (empirical LFL of 10% applies to inhalation environments; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).
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https://h2-papers.org/en/papers/30907314