H₂
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Safety Notes
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myocardial infarction
28 papers
Delivery-method distribution
inhalation: 10
hydrogen-rich water: 8
injection / infusion: 5
mixed routes: 4
not specified: 1
Acoustic hydrogen delivery to treat PANoptosis induced by myocardial ischemia/reperfusion injury in rats.
2026 ・ Biomater Adv ・ PMID 41671925
injection / infusion
positive
animal study
Application of Molecular Hydrogen in Early Heart Failure Development: Modulation of Microcirculation, Metabolism, Oxidative Stress, and Myocardial Status.
2025 ・ Antioxidants (Basel) ・ PMID 41462618
inhalation
positive
animal study
Exploring the Potential of Molecular Hydrogen in Different Heart Failure Models: A Review.
2025 ・ Int J Mol Sci ・ PMID 41373725
mixed routes
not assessed
review
Molecular Hydrogen as an Adjuvant Therapy in Severe Lupus Serositis With Heart Failure: A Case Report on Immune Modulation and Fatigue Reduction.
2025 ・ In Vivo ・ PMID 40010949
not specified
positive
human case report
The Protective Role of Molecular Hydrogen in Ischemia/Reperfusion Injury.
2024 ・ Int J Mol Sci ・ PMID 39063126
mixed routes
not assessed
review
Magnesium implantation as a continuous hydrogen production generator for the treatment of myocardial infarction in rats.
2024 ・ Sci Rep ・ PMID 38745034
mixed routes
positive
animal study
Molecular Hydrogen Reduces the Degree of Endothelial Alteration under Conditions of Chronic Heart Failure.
2023 ・ Bull Exp Biol Med ・ PMID 37773571
inhalation
positive
animal study
Hydrogen-rich saline alleviates cardiomyocyte apoptosis by reducing expression of calpain1 via miR-124-3p.
2023 ・ ESC Heart Fail ・ PMID 37602925
injection / infusion
positive
animal study
The Effect of Molecular Hydrogen on Functional States of Erythrocytes in Rats with Simulated Chronic Heart Failure.
2023 ・ Life (Basel) ・ PMID 36836774
inhalation
positive
animal study
Molecular hydrogen exposure improves functional state of red blood cells in the early postoperative period: a randomized clinical study.
2023 ・ Med Gas Res ・ PMID 36204784
inhalation
positive
human randomized controlled trial
Dynamics of Metabolic and Oxidative Parameters of Erythrocytes during Treatment of Chronic Heart Failure with Molecular Hydrogen.
2022 ・ Bull Exp Biol Med ・ PMID 36210415
inhalation
positive
human observational study
Effect of hydrogen-rich water on the lactic acid level in metformin-treated diabetic rats under hypoxia.
2021 ・ Korean J Physiol Pharmacol ・ PMID 34697262
hydrogen-rich water
positive
animal study
Hydrogen gas inhalation alleviates oxidative stress in patients with post-cardiac arrest syndrome.
2020 ・ J Clin Biochem Nutr ・ PMID 33041520
inhalation
mixed
human case report
Metabolomics Analysis of the Effect of Hydrogen-Rich Water on Myocardial Ischemia-Reperfusion Injury in Rats.
2020 ・ J Bioenerg Biomembr ・ PMID 32472432
hydrogen-rich water
positive
animal study
Effects of Hydrogen-rich Water on the PI3K/AKT Signaling Pathway in Rats with Myocardial Ischemia-reperfusion Injury.
2020 ・ Curr Mol Med ・ PMID 31702499
hydrogen-rich water
positive
animal study
Effect of hydrogen-rich water on the Nrf2/ARE signaling pathway in rats with myocardial ischemia-reperfusion injury.
2019 ・ J Bioenerg Biomembr ・ PMID 31768722
hydrogen-rich water
positive
animal study
Protein chip and bioinformatic analyses of differentially expressed proteins involved in the effect of hydrogen-rich water on myocardial ischemia-reperfusion injury.
2019 ・ Int J Med Sci ・ PMID 31588191
hydrogen-rich water
positive
animal study
A New Approach for the Prevention and Treatment of Cardiovascular Disorders. Molecular Hydrogen Significantly Reduces the Effects of Oxidative Stress.
2019 ・ Molecules ・ PMID 31159153
mixed routes
not assessed
review
Attenuation of Cardiac Ischaemia-reperfusion Injury by Treatment with Hydrogen-rich Water.
2019 ・ Curr Mol Med ・ PMID 30907314
hydrogen-rich water
positive
animal study
Regulation of microRNAs by molecular hydrogen contributes to the prevention of radiation-induced damage in the rat myocardium.
2019 ・ Mol Cell Biochem ・ PMID 30830529
hydrogen-rich water
positive
animal study
Promising novel therapy with hydrogen gas for emergency and critical care medicine.
2018 ・ Acute Med Surg ・ PMID 29657720
inhalation
not assessed
review
Protective effect of hydrogen-rich saline on pressure overload-induced cardiac hypertrophyin rats: possible role of JAK-STAT signaling.
2018 ・ BMC Cardiovasc Disord ・ PMID 29433438
injection / infusion
positive
animal study
Molecular hydrogen potentiates beneficial anti-infarct effect of hypoxic postconditioning in isolated rat hearts: a novel cardioprotective intervention.
2017 ・ Can J Physiol Pharmacol ・ PMID 28350967
injection / infusion
positive
animal study
The Effects of Hydrogen Gas Inhalation on Adverse Left Ventricular Remodeling After Percutaneous Coronary Intervention for ST-Elevated Myocardial Infarction - First Pilot Study in Humans.
2017 ・ Circ J ・ PMID 28321000
inhalation
mixed
human observational study
Hydrogen Inhalation is Superior to Mild Hypothermia in Improving Cardiac Function and Neurological Outcome in an Asphyxial Cardiac Arrest Model of Rats.
2016 ・ Shock ・ PMID 26849632
inhalation
positive
animal study
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