H₂
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reactive oxygen species
774 papers
Delivery-method distribution
hydrogen-rich water: 224
in vitro: 135
inhalation: 133
mixed routes: 118
not specified: 75
injection / infusion: 58
topical application: 14
animal model: 12
hydrogen bath: 5
Eumelanin-driven production of molecular hydrogen: A novel element of skin defense?
2015 ・ Med Hypotheses ・ PMID 25920542
not specified
not assessed
other
Hydrogen-rich water protects against ischemic brain injury in rats by regulating calcium buffering proteins.
2015 ・ Brain Res ・ PMID 25920370
hydrogen-rich water
positive
animal study
Hydrogen-Rich Medium Attenuated Lipopolysaccharide-Induced Monocyte-Endothelial Cell Adhesion and Vascular Endothelial Permeability via Rho-Associated Coiled-Coil Protein Kinase.
2015 ・ Shock ・ PMID 25895142
in vitro
positive
in vitro study
Hydrogen-rich water protects against acetaminophen-induced hepatotoxicity in mice.
2015 ・ World J Gastroenterol ・ PMID 25892869
hydrogen-rich water
positive
animal study
Protective effect of molecular hydrogen against oxidative stress caused by peroxynitrite derived from nitric oxide in rat retina.
2015 ・ Clin Exp Ophthalmol ・ PMID 25801048
in vitro
positive
in vitro study
Molecular hydrogen as a novel antioxidant: overview of the advantages of hydrogen for medical applications.
2015 ・ Methods Enzymol ・ PMID 25747486
mixed routes
not assessed
review
Targeting molecular hydrogen to mitochondria: barriers and gateways.
2015 ・ Pharmacol Res ・ PMID 25720951
not specified
not assessed
review
Simultaneous oral and inhalational intake of molecular hydrogen additively suppresses signaling pathways in rodents.
2015 ・ Mol Cell Biochem ・ PMID 25707580
mixed routes
positive
animal study
Effects of vitamin C, vitamin E, and molecular hydrogen on the placental function in trophoblast cells.
2015 ・ Arch Gynecol Obstet ・ PMID 25681223
in vitro
mixed
in vitro study
Stimulation of human damaged sperm motility with hydrogen molecule.
2015 ・ Med Gas Res ・ PMID 25649433
in vitro
positive
in vitro study
Combination therapy with nitric oxide and molecular hydrogen in a murine model of acute lung injury.
2015 ・ Shock ・ PMID 25643010
inhalation
positive
animal study
Hydrogen-rich water enhances cadmium tolerance in Chinese cabbage by reducing cadmium uptake and increasing antioxidant capacities.
2015 ・ J Plant Physiol ・ PMID 25543863
in vitro
positive
other
Molecular hydrogen in sports medicine: new therapeutic perspectives.
2015 ・ Int J Sports Med ・ PMID 25525953
mixed routes
not assessed
review
Spinal peroxynitrite contributes to remifentanil-induced postoperative hyperalgesia via enhancement of divalent metal transporter 1 without iron-responsive element-mediated iron accumulation in rats.
2015 ・ Anesthesiology ・ PMID 25501899
injection / infusion
positive
animal study
A systematic review of neuroprotective strategies after cardiac arrest: from bench to bedside (part II-comprehensive protection).
2014 ・ Med Gas Res ・ PMID 25671079
not specified
not assessed
review
Consumption of water containing over 3.5 mg of dissolved hydrogen could improve vascular endothelial function.
2014 ・ Vasc Health Risk Manag ・ PMID 25378931
hydrogen-rich water
positive
human randomized controlled trial
Hydrogen inhalation during normoxic resuscitation improves neurological outcome in a rat model of cardiac arrest independently of targeted temperature management.
2014 ・ Circulation ・ PMID 25366995
inhalation
positive
animal study
Molecular hydrogen in drinking water protects against neurodegenerative changes induced by traumatic brain injury.
2014 ・ PLoS One ・ PMID 25251220
hydrogen-rich water
positive
animal study
Inhaled hydrogen gas therapy for prevention of noise-induced hearing loss through reducing reactive oxygen species.
2014 ・ Neurosci Res ・ PMID 25196919
inhalation
positive
animal study
Hydrogen protects auditory hair cells from cisplatin-induced free radicals.
2014 ・ Neurosci Lett ・ PMID 25064701
in vitro
positive
in vitro study
Effects of hydrogen-rich water on aging periodontal tissues in rats.
2014 ・ Sci Rep ・ PMID 24985521
hydrogen-rich water
mixed
animal study
Molecular hydrogen attenuates neuropathic pain in mice.
2014 ・ PLoS One ・ PMID 24941001
hydrogen-rich water
positive
animal study
Therapeutic efficacy of infused molecular hydrogen in saline on rheumatoid arthritis: a randomized, double-blind, placebo-controlled pilot study.
2014 ・ Int Immunopharmacol ・ PMID 24929023
injection / infusion
positive
human randomized controlled trial
Hydrogen-rich saline promotes survival of retinal ganglion cells in a rat model of optic nerve crush.
2014 ・ PLoS One ・ PMID 24915536
injection / infusion
positive
animal study
Hydrogen gas presents a promising therapeutic strategy for sepsis.
2014 ・ Biomed Res Int ・ PMID 24829918
inhalation
not assessed
review
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