水素水摂取がラット加齢性歯周組織に与える影響
Oxidative stress is a key contributor to age-associated inflammatory processes in periodontal tissues. This animal study examined whether long-term consumption of hydrogen-rich water could modify age-related oxidative and inflammatory changes in healthy rats. Male Fischer 344 rats (4 months old, n=12) were allocated to either a hydrogen-rich water group or a distilled water control group and maintained until 16 months of age. At the endpoint, periodontal oxidative damage was significantly lower in the hydrogen-rich water group compared with controls. However, interleukin-1β protein expression did not differ between groups. Notably, gene expression of NLRP3 inflammasome components was elevated in the hydrogen-rich water group relative to controls. These findings suggest that hydrogen-rich water consumption may reduce age-related oxidative damage in periodontal tissues, while its influence on inflammatory signaling pathways appears limited or complex.
Hydrogen-rich water scavenges reactive oxygen species in periodontal tissues, reducing age-related oxidative damage. However, NLRP3 inflammasome gene expression was upregulated without corresponding changes in IL-1β protein, suggesting the anti-inflammatory effect is limited or pathway-specific.
Hydrogen-rich water is a low-risk delivery route, but the achievable systemic hydrogen dose is bounded. For clinical applications, inhalation is the most efficient route; inhalation, however, carries explosion risk, and concentration matters (empirical LFL of 10% applies to inhalation environments; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).
See also:
https://h2-papers.org/en/papers/24985521