水素富化水による放射線照射マウスの心臓保護効果の検討
Ionizing radiation causes tissue damage primarily through hydroxyl radical generation. This murine study investigated whether hydrogen-rich water (pure water saturated with molecular hydrogen) could protect cardiac tissue from radiation-induced injury. Mice receiving hydrogen-rich water showed suppression of myocardial degeneration following irradiation. Cardiac levels of malondialdehyde (MDA) and 8-hydroxydeoxyguanosine (8-OHdG), both markers of oxidative damage, were reduced, while endogenous antioxidant activity in myocardial tissue was elevated. These findings indicate that molecular hydrogen exerts a cardioprotective effect against radiation-induced oxidative injury in vivo, likely through selective scavenging of hydroxyl radicals.
Molecular hydrogen selectively scavenges hydroxyl radicals, reducing myocardial MDA and 8-OHdG accumulation while enhancing endogenous antioxidant defenses, thereby mitigating radiation-induced oxidative damage to cardiac tissue.
Hydrogen-rich water is a low-risk delivery route, but the achievable systemic hydrogen dose is bounded. For clinical applications, inhalation is the most efficient route; inhalation, however, carries explosion risk, and concentration matters (empirical LFL of 10% applies to inhalation environments; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).
See also:
https://h2-papers.org/en/papers/21116102