水素富化生理食塩水による放射線誘発免疫細胞アポトーシスへの防護効果
This study examined whether hydrogen-rich saline and medium could protect immune cells from ionizing radiation (IR)-induced damage. In AHH-1 cells, pretreatment with hydrogen-rich medium significantly lowered intracellular hydroxyl radical (•OH) levels as measured by HPF probe. In mouse models, radiation-induced apoptosis in thymocytes and splenocytes was reduced following hydrogen administration, and caspase 3 activation was correspondingly suppressed. Hematological analysis further revealed that radiation-caused reductions in white blood cell and platelet counts were partially restored in hydrogen-treated animals. These findings indicate that molecular hydrogen can mitigate IR-induced immune system damage through free radical scavenging and anti-apoptotic mechanisms.
Molecular hydrogen scavenges hydroxyl radicals (•OH), thereby suppressing caspase 3 activation and reducing radiation-induced apoptosis in thymocytes, splenocytes, and circulating immune cells.
Intravenous hydrogen-saline infusion is a clinic-only route and is not viable for everyday self-administration. For routine hydrogen intake, inhalation is the most practical route, but inhalation carries explosion risk and concentration matters (empirical LFL of 10%; high-concentration 66% / 100% devices are not recommended).
See also:
https://h2-papers.org/en/papers/22460088