日本語・Markdown

Evidence base for hydrogen-saline infusion

Hydrogen-saline intravenous infusion is a clinic-only delivery route. Clinical and animal studies are catalogued here; for routine intake, inhalation remains the most practical route (→ safety notes).

Related papers (73)

• Acoustic hydrogen delivery to treat PANoptosis induced by myocardial ischemia/reperfusion injury in rats.
  Biomater Adv 2026 — animal study — injection / infusion — positive
• Hydrogen Molecule Delivery System to Ischemic Intestine Using Resuscitative Endovascular Balloon Occlusion of Aorta in Hemorrhagic Shock-A Proof-of-Concept Study.
  Biomedicines 2026 — animal study — injection / infusion — positive
• Hemodialysis employing molecular hydrogen (H) enriched dialysis solution may improve dialysis related fatigue through impact on energy metabolism.
  Sci Rep 2025 — human observational study — injection / infusion — positive
• Modulating NLRP3 Inflammasome Activity and Enhancing Cortical Synaptic Plasticity: Nanoparticulate Hydrogen's Role in Relief of Post-traumatic Anxiety-like Behaviors in Rats.
  Mol Neurobiol 2025 — animal study — injection / infusion — positive
• Four-dimensional data independent acquisition proteomics and metabolomics reveal mechanisms of hydrogen-rich water at Zusanli (ST36) point against triple-negative breast cancer in mice.
  J Tradit Chin Med 2025 — animal study — injection / infusion — positive
• Protective Effect of Hydrogen-Rich Saline on Spinal Cord Damage in Rats.
  Pharmaceuticals (Basel) 2023 — animal study — injection / infusion — positive
• Hydrogen-rich saline regulates NLRP3 inflammasome activation in sepsis-associated encephalopathy rat model.
  Int Immunopharmacol 2023 — animal study — injection / infusion — positive
• Hydrogen-rich saline alleviates cardiomyocyte apoptosis by reducing expression of calpain1 via miR-124-3p.
  ESC Heart Fail 2023 — animal study — injection / infusion — positive
• Attenuation of Myocardial Fibrosis Using Molecular Hydrogen by Inhibiting the TGF-β Signaling Pathway in Spontaneous Hypertensive Rats.
  Am J Hypertens 2022 — animal study — injection / infusion — positive
• Evaluation of the hydrogen-rich water alleviation potential on mercury toxicity in earthworms using ATR-FTIR and LC-ESI-MS/MS spectroscopy.
  Environ Sci Pollut Res Int 2022 — animal study — injection / infusion — positive
• Treatment with Hydrogen-Rich Water Improves the Nociceptive and Anxio-Depressive-like Behaviors Associated with Chronic Inflammatory Pain in Mice.
  Antioxidants (Basel) 2022 — animal study — injection / infusion — positive
• Effects of hydrogen-rich saline in neuroinflammation and mitochondrial dysfunction in rat model of sepsis-associated encephalopathy.
  J Transl Med 2022 — animal study — injection / infusion — positive
• Pharmacokinetics of hydrogen administered intraperitoneally as hydrogen-rich saline and its effect on ischemic neuronal cell death in the brain in gerbils.
  PLoS One 2022 — animal study — injection / infusion — positive
• Protective Effects of a Hydrogen-Rich Preservation Solution in a Canine Lung Transplantation Model.
  Ann Thorac Surg 2021 — animal study — injection / infusion — positive
• Protective effects of hydrogen rich saline solution on ventral penile mathieu type flap with penile tourniquet application in rats.
  J Pediatr Urol 2021 — animal study — injection / infusion — positive
• Hydrogen alleviates acute lung injury induced by limb ischaemia/reperfusion in mice.
  Life Sci 2021 — animal study — injection / infusion — positive
• Molecular hydrogen attenuates methamphetamine-induced behavioral sensitization and activation of ERK-ΔFosB signaling in the mouse nucleus accumbens.
  Prog Neuropsychopharmacol Biol Psychiatry 2020 — animal study — injection / infusion — positive
• Protective effects of hydrogen‑rich saline against experimental diabetic peripheral neuropathy via activation of the mitochondrial ATP‑sensitive potassium channel channels in rats.
  Mol Med Rep 2020 — animal study — injection / infusion — positive
• Protective effects of a hydrogen-rich solution during cold ischemia in rat lung transplantation.
  J Thorac Cardiovasc Surg 2020 — animal study — injection / infusion — positive
• Protective Effects of Hydrogen-Rich Water Against Cartilage Damage in a Rat Model of Osteoarthritis by Inhibiting Oxidative Stress, Matrix Catabolism, and Apoptosis.
  Med Sci Monit 2020 — animal study — injection / infusion — positive
• Molecular hydrogen regulates PTEN-AKT-mTOR signaling via ROS to alleviate peritoneal dialysis-related peritoneal fibrosis.
  FASEB J 2020 — animal study — injection / infusion — positive
• Molecular hydrogen: potential in mitigating oxidative-stress-induced radiation injury.
  Can J Physiol Pharmacol 2019 — review — injection / infusion — positive
• Sustained release of bioactive hydrogen by Pd hydride nanoparticles overcomes Alzheimer's disease.
  Biomaterials 2019 — animal study — injection / infusion — positive
• Hydrogen-rich solution attenuates cold ischemia-reperfusion injury in rat liver transplantation.
  BMC Gastroenterol 2019 — animal study — injection / infusion — positive
• Organ preservation solution containing dissolved hydrogen gas from a hydrogen-absorbing alloy canister improves function of transplanted ischemic kidneys in miniature pigs.
  PLoS One 2019 — animal study — injection / infusion — positive
• Prevention of ischemia-induced hearing loss by intravenous administration of hydrogen-rich saline in gerbil.
  Neurosci Lett 2018 — animal study — injection / infusion — positive
• Hydrogen-Rich Saline Regulates Intestinal Barrier Dysfunction, Dysbiosis, and Bacterial Translocation in a Murine Model of Sepsis.
  Shock 2018 — animal study — injection / infusion — positive
• Novel haemodialysis (HD) treatment employing molecular hydrogen (H)-enriched dialysis solution improves prognosis of chronic dialysis patients: A prospective observational study.
  Sci Rep 2018 — human observational study — injection / infusion — positive
• Protective effect of hydrogen-rich saline on pressure overload-induced cardiac hypertrophyin rats: possible role of JAK-STAT signaling.
  BMC Cardiovasc Disord 2018 — animal study — injection / infusion — positive
• [Effect of hydrogen-rich water on the chondriosome damage and cytokines in brain tissue of rats with traumatic brain injury].
  Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2018 — animal study — injection / infusion — positive
• Translational Research of Peritoneal Dialysis Solution with Dissolved Molecular Hydrogen.
  Contrib Nephrol 2018 — animal study — injection / infusion — positive
• [Research progress of hydrogen-rich saline for eye diseases].
  Zhonghua Yan Ke Za Zhi 2018 — review — injection / infusion — not assessed
• Hydrogen Flush After Cold Storage as a New End-Ischemic Ex Vivo Treatment for Liver Grafts Against Ischemia/Reperfusion Injury.
  Liver Transpl 2018 — animal study — injection / infusion — positive
• Molecular hydrogen protects against ischemia-reperfusion injury in a mouse fatty liver model via regulating HO-1 and Sirt1 expression.
  Sci Rep 2018 — animal study — injection / infusion — positive
• Hydrogen-rich saline improves non‑alcoholic fatty liver disease by alleviating oxidative stress and activating hepatic PPARα and PPARγ.
  Mol Med Rep 2017 — animal study — injection / infusion — positive
• Protective effects of molecular hydrogen on steroid-induced osteonecrosis in rabbits via reducing oxidative stress and apoptosis.
  BMC Musculoskelet Disord 2017 — animal study — injection / infusion — positive
• Molecular hydrogen potentiates beneficial anti-infarct effect of hypoxic postconditioning in isolated rat hearts: a novel cardioprotective intervention.
  Can J Physiol Pharmacol 2017 — animal study — injection / infusion — positive
• Hydrogen-rich saline attenuates anxiety-like behaviors in morphine-withdrawn mice.
  Neuropharmacology 2017 — animal study — injection / infusion — positive
• Therapeutic effects of hydrogen on chronic graft-versus-host disease.
  J Cell Mol Med 2017 — animal study — injection / infusion — positive
• [Effect of hydrogen-rich water on the CD34 expression in lesion boundary brain tissue of rats with traumatic brain injury].
  Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2017 — animal study — injection / infusion — positive
• Protective effects of hydrogen rich water on the intestinal ischemia/reperfusion injury due to intestinal intussusception in a rat model.
  Med Gas Res 2017 — animal study — injection / infusion — positive
• Possible clinical effects of molecular hydrogen (H2) delivery during hemodialysis in chronic dialysis patients: Interim analysis in a 12 month observation.
  PLoS One 2017 — human observational study — injection / infusion — positive
• Dissolved molecular hydrogen (H) in Peritoneal Dialysis (PD) solutions preserves mesothelial cells and peritoneal membrane integrity.
  BMC Nephrol 2017 — animal study — injection / infusion — positive
• Treatment with Hydrogen-Rich Saline Delays Disease Progression in a Mouse Model of Amyotrophic Lateral Sclerosis.
  Neurochem Res 2016 — animal study — injection / infusion — positive
• Hydrogen-rich water attenuates brain damage and inflammation after traumatic brain injury in rats.
  Brain Res 2016 — animal study — injection / infusion — positive
• Developing imidazoles as CEST MRI pH sensors.
  Contrast Media Mol Imaging 2016 — in vitro study — injection / infusion — positive
• Neuroprotective Effect of Hydrogen-Rich Saline in Global Cerebral Ischemia/Reperfusion Rats: Up-Regulated Tregs and Down-Regulated miR-21, miR-210 and NF-κB Expression.
  Neurochem Res 2016 — animal study — injection / infusion — positive
• Hydrogen-Rich Saline as an Innovative Therapy for Cataract: A Hypothesis.
  Med Sci Monit 2016 — other — injection / infusion — not assessed
• [Effects of hydrogen-rich water on the expression of aquaporin 1 in the cerebral cortex of rat with traumatic brain injury].
  Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2016 — animal study — injection / infusion — positive
• Spinal peroxynitrite contributes to remifentanil-induced postoperative hyperalgesia via enhancement of divalent metal transporter 1 without iron-responsive element-mediated iron accumulation in rats.
  Anesthesiology 2015 — animal study — injection / infusion — positive
• Intravenous infusion of H2-saline suppresses oxidative stress and elevates antioxidant potential in Thoroughbred horses after racing exercise.
  Sci Rep 2015 — animal study — injection / infusion — positive
• Hydrogen-rich saline may be an effective and specific novel treatment for osteoradionecrosis of the jaw.
  Ther Clin Risk Manag 2015 — letter — injection / infusion — not assessed
• Sirtuin Type 1 Mediates the Retinal Protective Effect of Hydrogen-Rich Saline Against Light-Induced Damage in Rats.
  Invest Ophthalmol Vis Sci 2015 — animal study — injection / infusion — positive
• [Effects of hydrogen rich water on the expression of Nrf 2 and the oxidative stress in rats with traumatic brain injury].
  Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2015 — animal study — injection / infusion — positive
• Effect of a hydrogen (H2)-enriched solution on the albumin redox of hemodialysis patients.
  Hemodial Int 2014 — human randomized controlled trial — injection / infusion — positive
• Molecular hydrogen suppresses reactive astrogliosis related to oxidative injury during spinal cord injury in rats.
  CNS Neurosci Ther 2014 — animal study — injection / infusion — positive
• Hydrogen-rich saline promotes survival of retinal ganglion cells in a rat model of optic nerve crush.
  PLoS One 2014 — animal study — injection / infusion — positive
• Therapeutic efficacy of infused molecular hydrogen in saline on rheumatoid arthritis: a randomized, double-blind, placebo-controlled pilot study.
  Int Immunopharmacol 2014 — human randomized controlled trial — injection / infusion — positive
• Protective effects of hydrogen-rich saline on ulcerative colitis rat model.
  J Surg Res 2013 — animal study — injection / infusion — positive
• Transperitoneal administration of dissolved hydrogen for peritoneal dialysis patients: a novel approach to suppress oxidative stress in the peritoneal cavity.
  Med Gas Res 2013 — human case report — injection / infusion — positive
• Hydrogen-rich saline prevents neointima formation after carotid balloon injury by suppressing ROS and the TNF-α/NF-κB pathway.
  Atherosclerosis 2012 — animal study — injection / infusion — positive
• Hydrogen-rich saline protects retina against glutamate-induced excitotoxic injury in guinea pig.
  Exp Eye Res 2012 — animal study — injection / infusion — positive
• Hydrogen-rich saline protects spermatogenesis and hematopoiesis in irradiated BALB/c mice.
  Med Sci Monit 2012 — animal study — injection / infusion — positive
• Hydrogen-rich saline protects immunocytes from radiation-induced apoptosis.
  Med Sci Monit 2012 — animal study — injection / infusion — positive
• Protective effects of hydrogen-rich saline in a rat model of traumatic brain injury via reducing oxidative stress.
  J Surg Res 2012 — animal study — injection / infusion — positive
• Beneficial effect of hydrogen-rich saline on cerebral vasospasm after experimental subarachnoid hemorrhage in rats.
  J Neurosci Res 2012 — animal study — injection / infusion — positive
• Therapeutic effects of hydrogen saturated saline on rat diabetic model and insulin resistant model via reduction of oxidative stress.
  Chin Med J (Engl) 2012 — animal study — injection / infusion — positive
• Protective effects of hydrogen-rich saline in a rat model of permanent focal cerebral ischemia via reducing oxidative stress and inflammatory cytokines.
  Brain Res 2012 — animal study — injection / infusion — positive
• Protective effect of hydrogen-rich saline on decompression sickness in rats.
  Aviat Space Environ Med 2011 — animal study — injection / infusion — positive
• Hydrogen-rich saline ameliorates the severity of l-arginine-induced acute pancreatitis in rats.
  Biochem Biophys Res Commun 2010 — animal study — injection / infusion — positive
• Saturated hydrogen saline protects the lung against oxygen toxicity.
  Undersea Hyperb Med 2010 — animal study — injection / infusion — positive
• The hypothesis of an effective safe and novel radioprotective agent: hydrogen-rich solution.
  West Indian Med J 2010 — letter — injection / infusion — not assessed
• Hydrogen-rich saline protects myocardium against ischemia/reperfusion injury in rats.
  Exp Biol Med (Maywood) 2009 — animal study — injection / infusion — positive

Related safety notes

• inhalation-concentration
• lineage