分子状水素による酸化ストレス誘発性放射線障害軽減の可能性
This review examines the capacity of molecular hydrogen (H2) to scavenge reactive oxygen and nitrogen species in artificial radical-generating systems. In rat cardiac tissue, in vivo H2 administration produced significant elevations in superoxide dismutase activity and pAKT, a marker of cell survival signaling. Radiation-induced lipid peroxidation in rats was substantially reduced by H2 pre-treatment. The authors propose that Nrf2 (nuclear factor erythroid 2-related factor 2) pathway activation underlies these protective effects, promoting endogenous antioxidant defenses while suppressing apoptosis and inflammatory responses. These findings position H2 as a candidate agent for mitigating radiation-associated oxidative damage.
H2 is proposed to activate the Nrf2 pathway, upregulating endogenous antioxidant enzymes such as superoxide dismutase, reducing lipid peroxidation, and suppressing apoptosis and inflammation, while also enhancing cell survival via pAKT signaling.
Intravenous hydrogen-saline infusion is a clinic-only route and is not viable for everyday self-administration. For routine hydrogen intake, inhalation is the most practical route, but inhalation carries explosion risk and concentration matters (empirical LFL of 10%; high-concentration 66% / 100% devices are not recommended).
See also:
https://h2-papers.org/en/papers/30543459