シスプラチン誘発性アロディニアおよび機能的・情動的障害に対する水素富化水の予防的効果：雌雄マウスを用いた検討
Using C57BL/6J male and female mice administered cisplatin (CIS), this study evaluated whether prophylactic hydrogen-rich water (HRW) intake could mitigate CIS-associated pathologies. Outcomes assessed included tactile and cold allodynia, grip strength deficits, body weight changes, anxiodepressive-like behaviors, and inflammatory and oxidative responses in the dorsal root ganglia (DRG) and prefrontal cortex (PFC). Mechanical allodynia and anxiodepressive-like behaviors appeared comparably in both sexes, while cold allodynia, grip strength loss, and body weight reduction were more pronounced in females. HRW administration prevented all these impairments in both sexes. Concurrently, inflammatory and oxidative stress markers in the DRG and PFC were significantly suppressed by HRW, suggesting these pathways underlie the observed protective effects. The findings indicate that HRW warrants further investigation as a prophylactic approach against CIS-induced neuropathic and behavioral sequelae.
HRW is proposed to suppress cisplatin-activated inflammatory and oxidative stress responses in the dorsal root ganglia and prefrontal cortex, thereby reducing neuropathic allodynia and anxiodepressive-like behavioral deficits in both sexes.
Hydrogen-rich water is a low-risk delivery route, but the achievable systemic hydrogen dose is bounded. For clinical applications, inhalation is the most efficient route; inhalation, however, carries explosion risk, and concentration matters (empirical LFL of 10% applies to inhalation environments; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).
See also:
https://h2-papers.org/en/papers/38136183