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Modulating NLRP3 Inflammasome Activity and Enhancing Cortical Synaptic Plasticity: Nanoparticulate Hydrogen's Role in Relief of Post-traumatic Anxiety-like Behaviors in Rats.

ナノ粒子水素によるNLRP3インフラマソーム制御と皮質シナプス可塑性増強：外傷後不安様行動の軽減における役割

Abstract

Using a rat model of PTSD induced by single prolonged stress combined with electric foot shock (SPS&S), this study evaluated the effects of a magnesium hydrosilicide nanosheet (MSN) capable of sustained hydrogen release. A 7-day MSN administration regimen significantly reduced anxiety-like behaviors and reversed synaptic deficits in prefrontal cortical regions. Molecular analyses revealed downregulation of NLRP3 inflammasome components at both protein and mRNA levels, alongside restoration of neuroplasticity markers including brain-derived neurotrophic factor (BDNF) and postsynaptic density protein 95 (PSD95). These findings indicate that MSN-mediated hydrogen delivery simultaneously suppresses neuroinflammatory signaling and preserves synaptic integrity, offering a dual-action approach to PTSD-associated affective dysfunction.

Mechanism

Hydrogen released from magnesium hydrosilicide nanosheets suppresses NLRP3 inflammasome expression at protein and mRNA levels, reducing neuroinflammation, while simultaneously restoring BDNF and PSD95 levels to preserve synaptic plasticity in the prefrontal cortex.

Bibliographic

Authors

Wu L, Yang C, Ding Y, Liu X, Sun H, Li XM, et al.

Journal

Mol Neurobiol

Year

2025 (2025-11-20)

PMID

41261203

DOI

10.1007/s12035-025-05524-x

Tags

Delivery context

Intravenous hydrogen-saline infusion is a clinic-only route and is not viable for everyday self-administration. For routine hydrogen intake, inhalation is the most practical route, but inhalation carries explosion risk and concentration matters (empirical LFL of 10%; high-concentration 66% / 100% devices are not recommended).

Safety notes

See also:

• Inhalation concentration and LFL / UFL
• Consumer Affairs Agency accident cases
• Inhalation safety threshold lineage

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