水素水摂取が月経前症状の重症度および生活の質に与える影響：無作為化対照試験
A randomized controlled trial enrolled 65 women with premenstrual syndrome (PMS), allocated to an intervention group (n=33) consuming 1500–2000 mL of hydrogen-rich water (HRW) daily or a placebo water group (n=32). Participants followed the protocol from day 16 of their menstrual cycle through day 2 of the subsequent cycle across three consecutive cycles. Premenstrual Syndrome Scale (PMSS) scores were significantly lower in the HRW group at both the first and second follow-up assessments (P<0.05). At the first follow-up, the Physical Health and Psychological domains of the WHOQOL-BREF showed significantly higher scores in the HRW group compared to controls (P<0.05). A significant group-by-time interaction was detected for PMSS (F=10.54, P<0.001), whereas no such interaction reached significance for WHOQOL-BREF overall. These findings indicate that regular HRW consumption is associated with reduced PMS symptom severity and improvements in physical and psychological quality-of-life domains.
HRW's antioxidant and anti-inflammatory properties are proposed to reduce oxidative stress and inflammatory signaling during the premenstrual phase, thereby alleviating both somatic and psychological PMS symptoms.
Hydrogen-rich water is a low-risk delivery route, but the achievable systemic hydrogen dose is bounded. For clinical applications, inhalation is the most efficient route; inhalation, however, carries explosion risk, and concentration matters (empirical LFL of 10% applies to inhalation environments; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).
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https://h2-papers.org/en/papers/38532373