Role of Molecular Hydrogen in Skin Diseases and its Impact in Beauty.

Abstract

The skin, as the body's largest organ, serves as a primary barrier against environmental, physical, chemical, and biological stressors. These stressors generate reactive oxygen and nitrogen species, and when oxidant production exceeds the skin's antioxidant defense capacity, oxidative stress and chronic inflammation ensue. Downstream consequences include collagen fiber degradation and impaired skin cell function, contributing to conditions such as psoriasis, atopic dermatitis, and skin aging. This review consolidates current evidence on the role of oxidative stress in dermatological pathogenesis and its effects on patients' quality of life and physical appearance. The potential of molecular hydrogen to counteract oxidative stress in skin-related conditions is examined, with findings suggesting it may represent a promising investigational approach for various dermatological disorders.

Mechanism

Molecular hydrogen selectively scavenges reactive oxygen and nitrogen species, thereby reducing oxidative stress and chronic inflammation. This suppression is proposed to prevent collagen fiber degradation and preserve normal skin cell function in dermatological conditions.