70歳以上の高齢者における6ヶ月間の水素水摂取が加齢の分子・表現型バイオマーカーに与える影響：無作為化対照パイロット試験
A parallel-group randomized controlled pilot trial enrolled 40 older adults (mean age 76.0 ± 5.6 years; 20 women) who consumed either 0.5 L/day of hydrogen-rich water (HRW; 15 ppm H2) or a control beverage for 6 months. Telomere length increased in the HRW group (0.99 to 1.02) while decreasing in controls (0.92 to 0.79), yielding a significant group-by-time interaction (P = 0.049). The magnitude of TET2 expression elevation was significantly greater with HRW than with control water (P = 0.040). Brain metabolite levels—choline and NAA in the left frontal grey matter, creatine in the right parietal white matter, and NAA in the right parietal mesial grey matter—were significantly higher in the HRW group. Chair-stand performance also improved significantly with HRW (P = 0.01). No significant between-group differences were detected for other molecular, cognitive, body composition, skin, sleep, or quality-of-life endpoints.
H2 is proposed to act through pleiotropic mechanisms including suppression of telomere shortening, upregulation of TET2-mediated DNA methylation, and enhancement of brain metabolite concentrations (choline, NAA, creatine) in specific cortical regions.
Hydrogen-rich water is a low-risk delivery route, but the achievable systemic hydrogen dose is bounded. For clinical applications, inhalation is the most efficient route; inhalation, however, carries explosion risk, and concentration matters (empirical LFL of 10% applies to inhalation environments; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).
See also:
https://h2-papers.org/en/papers/34601077