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Evidence base for hydrogen baths and topical applications

Evidence on hydrogen bathing and localized applications. Systemic hydrogen uptake is most efficient via inhalation.

Related papers (28)

• An Iron-Scavenging and Hydrogen-Releasing Microneedle Patch Suppresses Ferroptosis and Promotes Spinal Cord Repair.
  ACS Nano 2026 — animal study — topical application — positive
• Local Visible-Photocatalytic Production of Hydrogen and Warm Heat for Combination Treatment of Pressure Ulcer.
  Adv Sci (Weinh) 2025 — animal study — topical application — positive
• Coaxial Fibrous Dressing Enabling Sequential NO/HRelease for Temporally Programmed Antibacterial and Healing-Promoting Functions in Infected Diabetic Wound Treatment.
  ACS Appl Mater Interfaces 2025 — animal study — topical application — positive
• Topically Applied Molecular Hydrogen Normalizes Skin Parameters Associated with Oxidative Stress: A Pilot Study.
  Antioxidants (Basel) 2025 — human case report — topical application — positive
• Transdermal hydrogen therapy for psoriasis using cavity-embedded double-conical microneedles.
  J Control Release 2025 — animal study — topical application — positive
• Efficacy of different nasal irrigation treatments versus placebo in allergic rhinitis: a systematic review and network meta-analysis.
  Front Pharmacol 2025 — meta-analysis — topical application — mixed
• Solid-state atomic hydrogen as a broad-spectrum RONS scavenger for accelerated diabetic wound healing.
  Natl Sci Rev 2024 — animal study — topical application — positive
• Hydrogen-producing Photocatalyst at Sunscreen for Athletes in Preventing and Healing Muscle-nerve-skin Injuries.
  Curr Top Med Chem 2023 — review — topical application — not assessed
• Two-Dimensional MgSi Nanosheet-Enabled Sustained Hydrogen Generation for Improved Repair and Regeneration of Deeply Burned Skin.
  Adv Healthc Mater 2023 — in vitro study — topical application — positive
• Effect and mechanism of hydrogen-rich bath on mice with imiquimod-induced psoriasis.
  Exp Dermatol 2023 — animal study — hydrogen bath — positive
• Hydrogen-rich bath with nano-sized bubbles improves antioxidant capacity based on oxygen radical absorbing and inflammation levels in human serum.
  Med Gas Res 2022 — human observational study — hydrogen bath — positive
• Symbiotic Algae-Bacteria Dressing for Producing Hydrogen to Accelerate Diabetic Wound Healing.
  Nano Lett 2022 — in vitro study — topical application — positive
• Prophylactic Instillation of Hydrogen-Rich Water Decreases Corneal Inflammation and Promotes Wound Healing by Activating Antioxidant Activity in a Rat Alkali Burn Model.
  Int J Mol Sci 2022 — animal study — topical application — positive
• Photocatalytic glucose depletion and hydrogen generation for diabetic wound healing.
  Nat Commun 2022 — animal study — topical application — positive
• Hydrotherapy with hydrogen-rich water compared with RICE protocol following acute ankle sprain in professional athletes: a randomized non-inferiority pilot trial.
  Res Sports Med 2021 — human randomized controlled trial — hydrogen bath — null
• Heat-retention effects of hydrogen-rich water bath assessed by thermography for humans.
  J Therm Biol 2021 — human observational study — hydrogen bath — positive
• Case Report: Acute hydrotherapy with super-saturated hydrogen-rich water for ankle sprain in a professional athlete.
  F1000Res 2020 — human case report — hydrogen bath — positive
• An Immunohistochemical Study of the Increase in Antioxidant Capacity of Corneal Epithelial Cells by Molecular Hydrogen, Leading to the Suppression of Alkali-Induced Oxidative Stress.
  Oxid Med Cell Longev 2020 — animal study — topical application — positive
• The Effects of Supersaturated Hydrogen-Rich Water Bathing on Biomarkers of Muscular Damage and Soreness Perception in Young Men Subjected to High-Intensity Eccentric Exercise.
  J Sports Med (Hindawi Publ Corp) 2020 — human randomized controlled trial — hydrogen bath — positive
• The Efficacy of Melanin Precursor QIAPI 1© Against Age-related Macular Degeneration (AMD): A Case Report.
  Cent Nerv Syst Agents Med Chem 2020 — human case report — topical application — mixed
• Antioxidant Activity of Hydrogen Water Mask Pack Composed of Gel-Type Emulsion and Hydrogen Generation Powder.
  Int J Mol Sci 2020 — human observational study — topical application — positive
• Effects of hydrogen-rich water bath on visceral fat and skin blotch, with boiling-resistant hydrogen bubbles.
  Med Gas Res 2019 — human case report — hydrogen bath — mixed
• Case Report: Buccal administration of hydrogen-producing blend after a mild traumatic brain injury in a professional athlete.
  F1000Res 2019 — human case report — topical application — positive
• Molecular Hydrogen Effectively Heals Alkali-Injured Cornea via Suppression of Oxidative Stress.
  Oxid Med Cell Longev 2017 — animal study — topical application — positive
• Accelerated healing of full thickness dermal wounds by macroporous waterborne polyurethane-chitosan hydrogel scaffolds.
  Mater Sci Eng C Mater Biol Appl 2017 — animal study — topical application — positive
• Therapeutic effect of molecular hydrogen in corneal UVB-induced oxidative stress and corneal photodamage.
  Sci Rep 2017 — animal study — topical application — positive
• A novel method of preserving cardiac grafts using a hydrogen-rich water bath.
  J Heart Lung Transplant 2013 — animal study — hydrogen bath — positive
• Protection of the retina by rapid diffusion of hydrogen: administration of hydrogen-loaded eye drops in retinal ischemia-reperfusion injury.
  Invest Ophthalmol Vis Sci 2010 — animal study — topical application — positive

Related safety notes

• inhalation-concentration
• accident-cases