Concentration-band classification of hydrogen inhalers

Overview

Related papers100

• Gas Therapies for Neuro-Protection.
  Crit Care Clin ・ 2026 ・ PMID 41260719
  inhalation not assessed review
• Hydrogen gas promotes neuroprotection and upregulates ATF5 expression in neonatal hypoxic-ischemic brain injury.
  Exp Neurol ・ 2026 ・ PMID 41386344
  inhalation positive animal study
• Sixty-minute inhalation of molecular hydrogen decreases blood oxygen saturation but does not alter autonomic cardiac regulation at rest in healthy females: a randomized, double-blind, placebo-controlled crossover study.
  Can J Physiol Pharmacol ・ 2026 ・ PMID 41401441
  inhalation mixed human randomized controlled trial
• Emerging Clinical Applications for Molecular Hydrogen.
  Respir Care ・ 2026 ・ PMID 41449652
  inhalation not assessed review
• Hydrogen inhalation is associated with a transient rightward shift in prefrontal oxyhemoglobin asymmetry and autonomic modulation.
  Sci Rep ・ 2026 ・ PMID 41582106
  inhalation positive human observational study
• Molecular hydrogen triggers TRPC4-TRPC4AP-dependent reversible calcium transients via extracellular influx.
  Theranostics ・ 2026 ・ PMID 41799190
  inhalation positive in vitro study
• [The combined use of inhaled nitric oxide and molecular hydrogen in patients with post-COVID-19 syndrome].
  Ter Arkh ・ 2026 ・ PMID 41859790
  inhalation positive human randomized controlled trial
• Neuroprotective Effects of Molecular Hydrogen via Oxidative Stress and Neuroinflammation Regulation in a 5xFAD Mouse Model.
  Antioxidants (Basel) ・ 2026 ・ PMID 41897548
  inhalation positive animal study
• Molecular Hydrogen Modulates the Baroreflex Activity and Reduces the Vascular Adrenoreceptor Sensitivity to Phenylephrine and Lung Inflammation in Rats with Pulmonary Hypertension.
  Biomedicines ・ 2026 ・ PMID 41898141
  inhalation positive animal study
• Hydrogen gas inhalation alleviated cerebral ischemia/reperfusion injury by regulating mitophagy in SH-SY5Y cells and mice via PTEN-induced kinase 1/Parkin pathway.
  J Stroke Cerebrovasc Dis ・ 2026 ・ PMID 42049119
  inhalation positive animal study
• Respiratory-physiology modeling of therapeutic hydrogen inhalation: defining the fraction of inspired hydrogen (FiH) and flow-rate requirements.
  Respir Res ・ 2026 ・ PMID 42050516
  inhalation not assessed other
• Effects of Inhalation of Hydrogen Gas on Allergic Conjunctivitis Model Mice.
  J Ocul Pharmacol Ther ・ 2026 ・ PMID 42101321
  inhalation positive animal study
• Inhalation of hydrogen gas reduces exacerbations of acute aortic dissection in mice.
  Life Sci ・ 2026 ・ PMID 42105975
  inhalation positive animal study
• Hydrogen restores central tryptophan and metabolite levels and maintains mitochondrial homeostasis to protect rats from chronic mild unpredictable stress damage.
  Neurochem Int ・ 2025 ・ PMID 39653185
  inhalation positive animal study
• Evaluation of the therapeutic effects of nebulized inhalation of hydrogen-rich water on primary blast lung injury in C57BL/6 mice.
  Surgery ・ 2025 ・ PMID 39799761
  inhalation positive animal study
• Molecular hydrogen inhalation modulates resting metabolism in healthy females: findings from a randomized, double-blind, placebo-controlled crossover study.
  Med Gas Res ・ 2025 ・ PMID 39923133
  inhalation positive human randomized controlled trial
• Hydrogen-oxygen mixture inhalation as an adjunctive treatment to home-based exercise in older patients with knee osteoarthritis: an open-label, blinded-endpoint, randomized controlled trial.
  Front Pharmacol ・ 2025 ・ PMID 39950118
  inhalation mixed human randomized controlled trial
• Performance of Unmodified Mechanical Ventilators With 2% Hydrogen Gas Mixtures.
  Respir Care ・ 2025 ・ PMID 39969918
  inhalation not assessed other
• [Efficiency and safety of the integrated use of medical gases thermal heliox, nitric oxide and molecular hydrogen in patients with exacerbation of chronic obstructive pulmonary disease complicated by hypoxemic, hypercapnic respiratory failure and secondary pulmonary arterial hypertension in the post-COVID period].
  Ter Arkh ・ 2025 ・ PMID 40327618
  inhalation positive human randomized controlled trial
• Molecular hydrogen mitigates traumatic brain injury-induced lung injury via NLRP3 inflammasome inhibition.
  BMC Chem ・ 2025 ・ PMID 40405232
  inhalation positive animal study
• Molecular hydrogen attenuates cisplatin-induced nephrotoxicity by modulating β-hydroxybutyrate metabolism.
  Mol Biol Rep ・ 2025 ・ PMID 40705191
  inhalation positive animal study
• Molecular hydrogen protects against sepsis-induced cardiomyopathy through improving Golgi stress-mediated autophagy, inflammation and apoptosis.
  Br J Pharmacol ・ 2025 ・ PMID 40717465
  inhalation positive animal study
• Hydrogen Gas Attenuates Toxic Metabolites and Oxidative Stress-Mediated Signaling to Inhibit Neurodegeneration and Enhance Memory in Alzheimer's Disease Models.
  Int J Mol Sci ・ 2025 ・ PMID 40725167
  inhalation positive animal study
• Clinical Efficacy of Hydrogen Therapy on Acute Radiation Enteritis and Inflammatory Response in Patients with Cervical Cancer Undergoing Concurrent Chemoradiation Therapy.
  Adv Radiat Oncol ・ 2025 ・ PMID 41020280
  inhalation positive human randomized controlled trial
• Gut microbiota as a central mediator in hydrogen gas-induced alleviation of colitis via TLR4/NF-κB and Nrf2 pathway regulation.
  Int Immunopharmacol ・ 2025 ・ PMID 41076929
  inhalation positive animal study
• Molecular hydrogen-mediated SIRT1 activation alleviates sepsis-associated encephalopathy by promoting mitophagy.
  Eur J Med Res ・ 2025 ・ PMID 41351127
  inhalation positive animal study
• Molecular Hydrogen Affords Similar Neuroprotection to Therapeutic Hypothermia in a Porcine Model of Neonatal Hypoxic-Ischemic Encephalopathy.
  Antioxidants (Basel) ・ 2025 ・ PMID 41462605
  inhalation positive animal study
• Application of Molecular Hydrogen in Early Heart Failure Development: Modulation of Microcirculation, Metabolism, Oxidative Stress, and Myocardial Status.
  Antioxidants (Basel) ・ 2025 ・ PMID 41462618
  inhalation positive animal study
• Molecular hydrogen attenuates sepsis-induced cardiomyopathy in mice by promoting autophagy.
  BMC Anesthesiol ・ 2024 ・ PMID 38395800
  inhalation positive animal study
• Hydrogen inhalation: in vivo rat genotoxicity tests.
  Mutat Res Genet Toxicol Environ Mutagen ・ 2024 ・ PMID 38432775
  inhalation null animal study
• Molecular Hydrogen as a Promising Therapy Could Be Linked With Increased Resting Treg Cells or Decreased Fas+ T Cell Subsets in a IgG4-PF-ILD Patient: A Case Report.
  In Vivo ・ 2024 ・ PMID 38688598
  inhalation positive human case report
• [Rehabilitation program of post-COVID-19 syndrome with the use of nitric oxide and molecular hydrogen].
  Ter Arkh ・ 2024 ・ PMID 38713041
  inhalation positive human randomized controlled trial
• Inhalation of hydrogen gas mitigates sevoflurane-induced neuronal apoptosis in the neonatal cortex and is associated with changes in protein phosphorylation.
  J Neurochem ・ 2024 ・ PMID 38849977
  inhalation positive animal study
• Molecular hydrogen promotes retinal vascular regeneration and attenuates neovascularization and neuroglial dysfunction in oxygen-induced retinopathy mice.
  Biol Res ・ 2024 ・ PMID 38915069
  inhalation positive animal study
• The impact of hydrogen inhalation therapy on blood reactive oxygen species levels: A randomized controlled study.
  Free Radic Biol Med ・ 2024 ・ PMID 38996821
  inhalation positive human randomized controlled trial
• Hinhalation therapy in patients with moderate COVID-19 (HCOVID): a prospective ascending-dose phase I clinical trial.
  Antimicrob Agents Chemother ・ 2024 ・ PMID 39016593
  inhalation positive human case report
• Realizing brain therapy with "smart medicine": mechanism and case report of molecular hydrogen inhalation for Parkinson's disease.
  Med Gas Res ・ 2024 ・ PMID 39073335
  inhalation positive human case report
• Combination of Hydrogen Inhalation and Hypothermic Temperature Control After Out-of-Hospital Cardiac Arrest: A Post hoc Analysis of the Efficacy of Inhaled Hydrogen on Neurologic Outcome Following Brain Ischemia During PostCardiac Arrest Care II Trial.
  Crit Care Med ・ 2024 ・ PMID 39133068
  inhalation mixed human randomized controlled trial
• Inhalation of H/O(66.7 %/33.3 %) mitigates depression-like behaviors in diabetes mellitus complicated with depression mice via suppressing inflammation and preventing hippocampal damage.
  Biomed Pharmacother ・ 2024 ・ PMID 39405908
  inhalation positive animal study
• The Role of Mast Cells in the Remodeling Effects of Molecular Hydrogen on the Lung Local Tissue Microenvironment under Simulated Pulmonary Hypertension.
  Int J Mol Sci ・ 2024 ・ PMID 39456794
  inhalation positive animal study
• Hydrogen Gas Inhalation Alleviates Airway Inflammation and Oxidative Stress on Ovalbumin-Induced Asthmatic BALB/c Mouse Model.
  Antioxidants (Basel) ・ 2024 ・ PMID 39594470
  inhalation positive animal study
• A case of lung injury due to a hydrogen explosion caused by the simultaneous use of two home folk remedies devices.
  Acute Med Surg ・ 2024 ・ PMID 39634382
  inhalation adverse human case report
• Molecular Hydrogen Mediates Neurorestorative Effects After Stroke in Diabetic Rats: the TLR4/NF-κB Inflammatory Pathway.
  J Neuroimmune Pharmacol ・ 2023 ・ PMID 35895245
  inhalation positive animal study
• Hydrogen Gas Inhalation Attenuates Acute Impulse Noise Trauma: A Preclinical In Vivo Study.
  Ann Otol Rhinol Laryngol ・ 2023 ・ PMID 35962590
  inhalation positive animal study
• Molecular hydrogen exposure improves functional state of red blood cells in the early postoperative period: a randomized clinical study.
  Med Gas Res ・ 2023 ・ PMID 36204784
  inhalation positive human randomized controlled trial
• Inhalation of 4% and 67% hydrogen ameliorates oxidative stress, inflammation, apoptosis, and necroptosis in a rat model of glycerol-induced acute kidney injury.
  Med Gas Res ・ 2023 ・ PMID 36204787
  inhalation positive animal study
• Molecular hydrogen attenuates sepsis-induced cognitive dysfunction through regulation of tau phosphorylation.
  Int Immunopharmacol ・ 2023 ・ PMID 36538853
  inhalation positive animal study
• Intermittent environmental exposure to hydrogen prevents skin photoaging through reduction of oxidative stress.
  Geriatr Gerontol Int ・ 2023 ・ PMID 36807963
  inhalation positive animal study
• The Effect of Molecular Hydrogen on Functional States of Erythrocytes in Rats with Simulated Chronic Heart Failure.
  Life (Basel) ・ 2023 ・ PMID 36836774
  inhalation positive animal study
• Efficacy of inhaled hydrogen on neurological outcome following brain ischaemia during post-cardiac arrest care (HYBRID II): a multi-centre, randomised, double-blind, placebo-controlled trial.
  EClinicalMedicine ・ 2023 ・ PMID 36969346
  inhalation mixed human randomized controlled trial
• Molecular hydrogen promotes wound healing by inducing early epidermal stem cell proliferation and extracellular matrix deposition.
  Inflamm Regen ・ 2023 ・ PMID 36973725
  inhalation positive animal study
• Effects of Hydrogen Gas Inhalation on Community-Dwelling Adults of Various Ages: A Single-Arm, Open-Label, Prospective Clinical Trial.
  Antioxidants (Basel) ・ 2023 ・ PMID 37371971
  inhalation positive human observational study
• Hydrogen Attenuates Inflammation by Inducing Early M2 Macrophage Polarization in Skin Wound Healing.
  Pharmaceuticals (Basel) ・ 2023 ・ PMID 37375833
  inhalation positive animal study
• Inhaled molecular hydrogen reduces hippocampal neuroinflammation, glial reactivity and ameliorates memory impairment during systemic inflammation.
  Brain Behav Immun Health ・ 2023 ・ PMID 37449286
  inhalation positive animal study
• Molecular hydrogen: prospective treatment strategy of kidney damage after cardiac surgery.
  Can J Physiol Pharmacol ・ 2023 ・ PMID 37463517
  inhalation positive animal study
• Attenuation of pulmonary damage in aged lipopolysaccharide-induced inflammation mice through continuous 2 % hydrogen gas inhalation: A potential therapeutic strategy for geriatric inflammation and survival.
  Exp Gerontol ・ 2023 ・ PMID 37572992
  inhalation mixed animal study
• Antitumoral Activity of Molecular Hydrogen and Proton in the Treatment of Glioblastoma: An Atypical Pharmacology?
  Brain Sci ・ 2023 ・ PMID 37626524
  inhalation not assessed review
• Molecular Hydrogen Reduces the Degree of Endothelial Alteration under Conditions of Chronic Heart Failure.
  Bull Exp Biol Med ・ 2023 ・ PMID 37773571
  inhalation positive animal study
• The efficacy of hydrogen/oxygen therapy favored the recovery of omicron SARS-CoV-2 variant infection: results of a multicenter, randomized, controlled trial.
  J Clin Biochem Nutr ・ 2023 ・ PMID 37970554
  inhalation positive human randomized controlled trial
• Hyperbaric hydrogen therapy improves secondary brain injury after head trauma.
  Undersea Hyperb Med ・ 2023 ・ PMID 38055881
  inhalation positive animal study
• Hydrogen Inhalation Reduces Lung Inflammation and Blood Pressure in the Experimental Model of Pulmonary Hypertension in Rats.
  Biomedicines ・ 2023 ・ PMID 38137362
  inhalation mixed animal study
• Molecular hydrogen alleviates lung injury after traumatic brain injury: Pyroptosis and apoptosis.
  Eur J Pharmacol ・ 2022 ・ PMID 34883075
  inhalation positive animal study
• Molecular Hydrogen Positively Affects Physical and Respiratory Function in Acute Post-COVID-19 Patients: A New Perspective in Rehabilitation.
  Int J Environ Res Public Health ・ 2022 ・ PMID 35206179
  inhalation positive human randomized controlled trial
• Development of a novel porcine ischemia/reperfusion model inducing different ischemia times in bilateral kidneys-effects of hydrogen gas inhalation.
  Transl Androl Urol ・ 2022 ・ PMID 35558259
  inhalation mixed animal study
• Hydrogen Gas Inhalation Regressed Coronary Artery Aneurysm in Kawasaki Disease-Case Report and Article Review.
  Front Cardiovasc Med ・ 2022 ・ PMID 35647081
  inhalation positive human case report
• Post-COVID-19 fatigue: A systematic review.
  Front Psychiatry ・ 2022 ・ PMID 36032234
  inhalation positive review
• Dynamics of Metabolic and Oxidative Parameters of Erythrocytes during Treatment of Chronic Heart Failure with Molecular Hydrogen.
  Bull Exp Biol Med ・ 2022 ・ PMID 36210415
  inhalation positive human observational study
• The effects of hydrogen treatment in a cigarette smoke solution-induced chronic obstructive pulmonary disease-like changes in an animal model.
  J Thorac Dis ・ 2022 ・ PMID 36524091
  inhalation positive animal study
• Hydrogen gas and preservation of intestinal stem cells in mesenteric ischemia and reperfusion.
  World J Gastrointest Surg ・ 2022 ・ PMID 36632117
  inhalation positive animal study
• Hydrogen and therapeutic gases for neonatal hypoxic-ischemic encephalopathy: potential neuroprotective adjuncts in translational research.
  Pediatr Res ・ 2021 ・ PMID 32505123
  inhalation not assessed review
• Hydrogen Gas Alleviates Sepsis-Induced Brain Injury by Improving Mitochondrial Biogenesis Through the Activation of PGC-α in Mice.
  Shock ・ 2021 ・ PMID 32590694
  inhalation positive animal study
• Molecular hydrogen downregulates acute exhaustive exercise-induced skeletal muscle damage.
  Can J Physiol Pharmacol ・ 2021 ・ PMID 33356867
  inhalation positive animal study
• Hydrogen as a Potential Therapeutic in Obesity: Targeting the Brain.
  Trends Endocrinol Metab ・ 2021 ・ PMID 33485760
  inhalation not assessed review
• Hydrogen Gas Therapy Attenuates Inflammatory Pathway Signaling in Septic Mice.
  J Surg Res ・ 2021 ・ PMID 33639371
  inhalation positive animal study
• Chemical and Biochemical Aspects of Molecular Hydrogen in Treating Kawasaki Disease and COVID-19.
  Chem Res Toxicol ・ 2021 ・ PMID 33719401
  inhalation not assessed review
• Inhaled gases as novel neuroprotective therapies in the postcardiac arrest period.
  Curr Opin Crit Care ・ 2021 ・ PMID 33769417
  inhalation not assessed review
• Hydrogen gas alleviates sepsis-induced neuroinflammation and cognitive impairment through regulation of DNMT1 and DNMT3a-mediated BDNF promoter IV methylation in mice.
  Int Immunopharmacol ・ 2021 ・ PMID 33773206
  inhalation positive animal study
• Molecular hydrogen alleviates asthma through inhibiting IL-33/ILC2 axis.
  Inflamm Res ・ 2021 ・ PMID 33852061
  inhalation positive animal study
• Protective effects of hydrogen gas inhalation on radiation-induced bone marrow damage in cancer patients: a retrospective observational study.
  Med Gas Res ・ 2021 ・ PMID 33942780
  inhalation positive human observational study
• Molecular Hydrogen Maintains the Storage Quality of Chinese Chive through Improving Antioxidant Capacity.
  Plants (Basel) ・ 2021 ・ PMID 34072565
  inhalation positive other
• Inhalation of Molecular Hydrogen, a Rescue Treatment for Noise-Induced Hearing Loss.
  Front Cell Neurosci ・ 2021 ・ PMID 34140880
  inhalation mixed animal study
• Randomized double-blind placebo-controlled trial of hydrogen inhalation for Parkinson's disease: a pilot study.
  Neurol Sci ・ 2021 ・ PMID 34319514
  inhalation null human randomized controlled trial
• Application of Molecular Hydrogen in Heart Surgery under Cardiopulmonary Bypass.
  Sovrem Tekhnologii Med ・ 2021 ・ PMID 34513069
  inhalation positive human observational study
• Inhalation of 2% Hydrogen Improves Survival Rate and Attenuates Shedding of Vascular Endothelial Glycocalyx in Rats with Heat Stroke.
  Shock ・ 2021 ・ PMID 34524269
  inhalation positive animal study
• High concentration of hydrogen gas alleviates Lipopolysaccharide-induced lung injury via activating Nrf2 signaling pathway in mice.
  Int Immunopharmacol ・ 2021 ・ PMID 34634688
  inhalation positive animal study
• Effect of hydrogen gas inhalation on patient QOL after hepatectomy: protocol for a randomized controlled trial.
  Trials ・ 2021 ・ PMID 34674744
  inhalation not assessed human randomized controlled trial
• The effects of inhaling hydrogen gas on macrophage polarization, fibrosis, and lung function in mice with bleomycin-induced lung injury.
  BMC Pulm Med ・ 2021 ・ PMID 34719405
  inhalation positive animal study
• Molecular Hydrogen: A Promising Adjunctive Strategy for the Treatment of the COVID-19.
  Front Med (Lausanne) ・ 2021 ・ PMID 34746162
  inhalation not assessed review
• Therapeutic Effects of Hydrogen Gas Inhalation on Trimethyltin-Induced Neurotoxicity and Cognitive Impairment in the C57BL/6 Mice Model.
  Int J Mol Sci ・ 2021 ・ PMID 34948107
  inhalation positive animal study
• Inhaled molecular hydrogen attenuates intense acute exercise-induced hippocampal inflammation in sedentary rats.
  Neurosci Lett ・ 2020 ・ PMID 31715290
  inhalation positive animal study
• Molecular hydrogen attenuates sepsis-induced neuroinflammation through regulation of microglia polarization through an mTOR-autophagy-dependent pathway.
  Int Immunopharmacol ・ 2020 ・ PMID 32058932
  inhalation positive animal study
• A "philosophical molecule," hydrogen may overcome senescence and intractable diseases.
  Med Gas Res ・ 2020 ・ PMID 32189669
  inhalation not assessed review
• Constitutive hydrogen inhalation prevents vascular remodeling via reduction of oxidative stress.
  PLoS One ・ 2020 ・ PMID 32302306
  inhalation positive animal study
• Chronic molecular hydrogen inhalation mitigates short and long-term memory loss in polymicrobial sepsis.
  Brain Res ・ 2020 ・ PMID 32348775
  inhalation positive animal study
• Hydrogen gas alleviates blood-brain barrier impairment and cognitive dysfunction of septic mice in an Nrf2-dependent pathway.
  Int Immunopharmacol ・ 2020 ・ PMID 32447221
  inhalation positive animal study
• Pharmacokinetics of a single inhalation of hydrogen gas in pigs.
  PLoS One ・ 2020 ・ PMID 32559239
  inhalation not assessed animal study
• Hydrogen gas inhalation improves delayed brain injury by alleviating early brain injury after experimental subarachnoid hemorrhage.
  Sci Rep ・ 2020 ・ PMID 32704088
  inhalation positive animal study
• Hydrogen Gas Inhalation Attenuates Endothelial Glycocalyx Damage and Stabilizes Hemodynamics in a Rat Hemorrhagic Shock Model.
  Shock ・ 2020 ・ PMID 32804466
  inhalation positive animal study
• Hydrogen inhalation inhibits microglia activation and neuroinflammation in a rat model of traumatic brain injury.
  Brain Res ・ 2020 ・ PMID 32814064
  inhalation positive animal study
• COVID-19 and molecular hydrogen inhalation.
  Ther Adv Respir Dis ・ 2020 ・ PMID 32865158
  inhalation not assessed letter

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